Publications

2017

  1. R. Branchford, T.J. Stalker, L. Law, G. Acevedo, S. Sather, C. Brzezinski, K.M. Wilson, K. Minson, A.B. Lee-Sherick, P. Davizon-Castillo, C. Ng, W. Zhang, K.B. Neeves, S.R. Lentz, X. Wang, S.V. Frye, H.S. Earp III, D. DeRyckere, L.F. Brass, D.K. Graham, J.A. Di Paola. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. Journal of Thrombosis and Haemostasis, in press.
  2. O. Tasci, D. Disharoon, R.M. Schoeman, K. Rana, P.S. Herson, D.W.M. Marr, K.B. Neeves. Enhanced fibrinolysis with magnetically powered colloidal microwheels. Small, 13 (2017)L 1700954. PMID:28719063
  3. T. Yang, T.O. Tasci, K.B. Neeves, N. Wu, D.W.M. Marr. Magnetic microlassos for reversible cargo capture, transport, and release. Langmuir, 33 (2017): 5932-5937. PMID:28318267
  4. M. Schoeman, M. Lehmann, K.G. Neeves. Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders. Platelets, 28 (2017): 463-471. PMID:28532218
  5. Cooper, S. Lloyd, A. Koch, X. Lin, K. Dobbs, T. Theisen, M. Zuberbuehler, T. Tenpas, K. Bernhardt, M. Gyorfi, S. Hying, S. Mortimer, C. Lamont, M. Lehmann, K. Neeves. Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels. Journal of Comparative Physiology B, 187 (2017): 815-825. PMID: 28332020
  6. B.L. Walton, M. Lehmann, T. Skorczewski, L.A. Holle, J.D. Beckman, J.A. Cribb, M.J. Mooberry, A.R. Wufsus, B.C. Cooley, J.W. Homeister, R. Pawlinski, M.R. Falvo, A.L. Falvo, N.S. Key, A.L. Fogelson, K.B. Neeves, A.S. Wolberg. Elevated hematocrit enhances platelet accumulation following vascular injury. Blood, 129 (2017): 2537-2546. PMID:28251913
  7. U. Naik, P. Patel, R. Derstine, R. Turaga, X. Chen, K. Golla, K.B. Neeves, H. Ichijo, U.P. Naik. Apoptosis signal-regulating kinase 1 regulates platelet granule secretion, thromboxane A2 generation, and thrombus formation in mice. Blood, 129:1197-1209. PMID:28028021
  8. M. Schoeman, K. Rana, N. Danes, M. Lehmann, J.A. Di Paola, A.L. Fogelson, K. Leiderman, K.B. Neeves. A microfluidic model of hemostasis sensitive to platelet function and coagulation. Cellular and Molecular Bioengineering, 10 (2017): 3-15. PMID:28529666

2016

  1. J. Maier, T. Lachner, A. Vilfan, T.O. Tasci, K.B. Neeves, D.W.M. Marr, and T.M. Fischer. Non reciprocal skewed rolling of a colloidal wheel due to induced chirality. Soft Matter,12:9314-9320. PMID: 27824198
  2. L. Wang, K.B. Neeves, E. Ozkan, X. Yin. Effect of pore-size distribution on phase transition of hydrocarbon mixtures in nanoporous media. SPE Journal, 21 (2016): 1981-1995.
  3. Y. Guo, J. Huang, F. Xiao, X. Yin, J. Chun, W. Um, K.B. Neeves, N. Wu. Bead-based microfluidic sediment analogs: Fabrication and colloid transport. Langmuir, 32:9342-50. doi:10.1021/acs.langmuir.6b02184PMID:27548505
  4. K. Rana, K.B. Neeves. Blood flow and mass transfer regulation of coagulation. Blood Reviews, 30 (2016): 357-368. PMID: 27133256
  5. O.J.T. McCarty, D. Ku, M. Sugimoto, M.R. King, J. Cosemans, K.B. Neeves. Dimensional analysis and scaling relevant to flow models of thrombus formation. Journal of Thrombosis and Haemostasis, 14 (2016): 619-622. PMID: 26933837
  6. K.B. Roth, K.B. Neeves, J. Squier, D.W.M. Marr. High-throughput linear optical stretcher for mechanical characterization of blood cells. Cytometry: Part A, 89 (2016): 391-397. PMID: 26565892
  7. T.O. Tasci, P.S. Herson, K.B. Neeves, D.W.M. Marr. Surface-enabled propulsion and control of colloidal microwheels. Nature Communications, 7 (2016): 10225. doi:10.1038/ncomms10225 , PMID:26725747

2015

  1. S. Zhu, B.A. Herbig, R. Li, T.V. Colace, R.W. Muthard, K.B. Neeves, S.L. Diamond. In microfluidico: Recreating in vivo hemodynamics using miniaturized devices. Biorheology, 52 (2015): 303-318. PMID: 26600269
  2. M. Lehmann, A.M. Wallbank, K.A. Dennis, A.R. Wufsus, K.M. Davis, K. Rana, K.B. Neeves. On-chip recalcification of citrated whole blood using a microfluidic herringbone mixer. Biomicrofluidics, 6 (2015): 064106. PMID:26634014
  3. K. He, L. Xu, Y. Gao, X. Yin, K.B. Neeves. Evaluation of surfactant performance in fracturing fluids for enhanced well productivity in the unconventional reservoirs using rock-on-a-chip approach. Journal of Petroleum Science and Engineering, 136 (2015): 531-541.
  4. KB. Neeves. Physiochemical artifacts in FeCl3 thrombosis models. Blood, 126 (2015): 700-701. PMID:26251225
  5. J.L. Sylman, D.T. Artzer, K. Rana, K.B. Neeves. A vascular injury model using focal heat-induced activation of endothelial cells. Integrative Biology, 15 (2015): 801-814. PMID:26087748
  6. B.R. Branchford, C.J. Ng, K.B. Neeves, J.A. Di Paola. Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis. Thrombosis Research, 136 (2015): 13-19. PMID:26014643
  7. K.B. Roth, K.B Neeves, J. Squier, D.W.M. Marr. Imaging of a linear diode bar for an optical cell stretcher. Biomedical Optics Express, 6 (2015): 807-814. PMID: 25798305
  8. K.B. Neeves. Down is a hole: A new laser ablation model of hemostasis. Journal of Thrombosis and Haemostasis, 13 (2015): 414-416. PMID:25510738
  9. A.R. Wufsus, K. Rana, A. Brown, J.R. Dorgan, M.W. Liberatore, K.B. Neeves. Elastic behavior and platelet retraction in low and high density fibrin gels. Biophysical Journal, 108 (2015): 173-183. PMID:25564864
  10. A.L. Fogelson, K.B. Neeves. Fluid mechanics of blood clot formation. Annual Reviews of Fluid Mechanics, 47 (2015): 377-403.

2014

  1. K. Rana, B.J. Timmer, K.B. Neeves. A combined microfluidic-microstencil method for patterning molecules and cells. Biomicrofluidics, 8 (2014): 056502. PMID: 25332748
  2. J.N. Thon, L. Mazutis, S Wu, J.L. Sylman, A. Ehrlicher, K.R. Machlus, Q. Feng, S. Lu, R. Lanza, K.B. Neeves, D.A. Weitz, J.E. Italiano Jr. Platelet bioreactor-on-a-chip. Blood, 124 (2014): 1857-1867. PMID: 25049277
  3. W. Xu, J.T. Ok, F. Xiao, K.B. Neeves, X.Y. Yin. The effect of pore geometry and interfacial tension on water-oil displacement efficiency in oil-wet microfluidic porous media analogs. Physics of Fluids, 26 (2014): 093102.
  4. J.L. Sylman, S.M. Lantvit, M.M. Reynolds, K.B. Neeves. The relative role of soluble guanylyl cylase dependent and independent pathways in nitric oxide inhibition of platelet aggregation under flow. Cellular and Molecular Bioengineering, 7 (2014): 421-431. Selected for Young Innovator Special Issue.
  5. Q. Wu, B. Bai, Y. Ma, J.T. Ok, K.B. Neeves, X. Yin. Optic imaging of two-phase flow behavior in one-dimensional nano-scale channels. SPE Journal, 19 (2014): 793-802.
  6. S. Ahmad, A. Ahmad, K.B. Neeves, J.E. Loader, T. Hendry-Hofer, C.W. White, L. Veress. In vitro cell culture model for toxic inhaled chemical testing. Journal of Visualized Experiments, 87 (2014): e51539. PMID: 24837339
  7. A.A. Onasoga-Jarvis, T.J. Puls, S.K. O’Brien, L Kuang, H.J. Liang, K.B. Neeves. Thrombin generation and fibrin formation under flow on biomimetic tissue factor rich surfaces. Journal of Thrombosis and Haemostasis,12 (2014): 372-382. PMID: 24345079
  8. K.B. Neeves, O.J.T. McCarty, A.J. Reininger, M. Sugimoto, M.R. King. Flow-dependent thrombin and fibrin generation: Opportunities for standardization. Journal of Thrombosis and Haemostasis, 12 (2014): 418-420. PMID: 24330648

2013

  1. A.A. Onasoga-Jarvis, K. Leiderman, A.L. Fogelson, M. Wang, M.J. Manco-Johnson, J.A. Di Paola, K.B. Neeves. The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. PLoS One, 8 (2013): e78732. PMID: 24236042
  2. J.L. Sylman, S.M. Lantvit, M.C. VeDepo, M.M. Reynolds, K.B. Neeves. Transport limitations of nitric oxide inhibition of platelet aggregation under flow. Annals of Biomedical Engineering, 41 (2013): 2193-2205. PMID: 23563992
  3. J.L. Sylman, K.B. Neeves. An inquiry-based investigation of controlled release drug delivery from hydrogels: An experiment for high school chemistry and biology. Journal of Chemical Education, 90 (2013): 918-921.
  4. K.B. Neeves, A.A. Onasoga, A.R. Wufsus. The use of microfluidics in hemostasis: Clinical diagnostics and biomimetic models of vascular injury. Current Opinion in Hematology, 20 (2013):417-423. PMID: 23872531
  5. A.R. Wufsus, N.E. Macera, K.B. Neeves. The hydraulic permeability of blood clots as a function of fibrin and platelet density. Biophysical Journal, 104 (2013): 1812-1823. Featured in New and Notable editorial. PMID: 23601328
  6. K.B. Roth, C.D. Eggleton, K.B. Neeves, D.W.M. Marr. Measuring cell mechanics by optical alignment compression cytometry. Lab on a Chip, 13 (2013): 1571-1577. PMID: 23440063
  7. Q. Wu, J.T. Ok, Y. Sun, S.T. Retterer, K.B. Neeves, X. Yin, B. Bai, Y. Ma. Optic imaging of single and two-phase pressure driven flow in nano-scale channels. Lab on a Chip, 13 (2013): 1165-1171. PMID: 23370894
  8. K.B. Neeves, A.A. Onasoga, R.R. Hansen, J.J. Lilly, D. Venckunaite, M.B. Sumner, A.T. Irish, G. Brodsky, M.J. Manco-Johnson, J.A. Di Paola. Sources of variability in platelet accumulation on type I fibrillar collagen in microfluidic flow assays. PLoS One, 8 (2013): e54680, doi:10.1371/journal.pone.0054680. PMID: 23355889
  9. R.R. Hansen, A.R. Wufsus, S.T. Barton, A.A. Onasoga, R.M. Johnson-Paben, K.B. Neeves. High content analysis of shear dependent platelet function in a microfluidic flow assay. Annals of Biomedical Engineering, 14 (2013): 250-262. PMID: 23301359
  10. S. Ahmad, A. Ahmad, R.C. Rancourt, K.B. Neeves, J.E. Loader, T. Hendry-Hofer, J. Di Paola, S.D. Reynolds, C.W. White. Tissue factor signals airway epithelial basal cell survival via coagulation and PAR1/2. American Journal of Respiratory Cell and Molecular Biology, 48 (2013): 94-104. PMID: 23065128
  11. K.B. Neeves. Collagen-induced thrombosis in large vessels using native prothrombotic substrates. Thrombosis Research, 131 (2013), 1-2. PMID: 23174625

2012

  1. V.K. Gupta, K.B. Neeves, C.D. Eggleton. Effect of viscoelasticity on the analysis of single molecule force spectroscopy on live cells.  Biophysical Journal, 103 (2012), 137-145. PMID: 22828340
  2. K.B. Neeves. Catch me if you can: Isolating circulating tumor cells from flowing blood.  Clinical Chemistry, 58 (2012), 803-804. PMID: 22353214
  3. C.P. Foley, N. Nishimura, K.B. Neeves, C.B. Schaffer, W.L. Olbricht. Real-time imaging of perivascular transport of nanoparticles during convection enhanced delivery in the rat cortex.  Annals of Biomedical Engineering, 40 (2012), 292-303. PMID: 22009318
  4. S. Ahmad, D. O. Raemy, J. E. Loader, J. M. Kailey, K. B. Neeves, C. W. White, A. Ahmad, P. Gehr, B. M. Rothen-Rutishauser.  Interaction and localization of synthetic nanoparticles in healthy and cystic fibrosis airway epithelial cells: Effect of ozone exposure. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(2012), 7-15. PMID: 23065128
  5. M. Wu, F. Xiao, R.M. Johnson-Paben, S.T. Retterer, X. Yin, K.B. Neeves.  Single- and two-phase flow in microfluidic porous media analogs based on Voronoi tessellation.  Lab on a Chip, 12 (2012), 253-261. Cover Article. PMID: 22094719

2010-2011

  1. R.R. Hansen, A.A. Tipnis, T.C. White-Adams, J.A. Di Paola, K.B. Neeves.  Characterization of collagen thin films for von Willebrand factor binding and platelet adhesion.  Langmuir, 27 (2011), 13648-13658. PMID: 21967679
  2. K.B. Neeves, D.A.R. Illing, S.L. Diamond.  Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow.  Biophysical Journal, 98 (2010), 1344-1352. PMID: 20371335
  3. W.L. Olbricht, K.B. Neeves, C.P. Foley.  Microfluidic probes in the treatment of brain-related diseases.  Drug News and Perspectives, 23 (2010), 491-497. PMID: 21031165 
  4. K.M. Wannemacher, L. Zhu, H. Jiang, K.P. Fong, T.J. Stalker, D. Lee, A.N. Tran, K.B. Neeves, S. Maloney, A. Kumanogoh, H. Kikutani, D.A. Hammer, S.L. Diamond, L.F. Brass.  Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.  Blood, 116 (2010), 5707-5715. PMID: 20855865

2008-2009

  1. A.A. Schmaier, Z. Zou, A. Kazlauskas, L. Emert-Sedlak, K.P. Fong, K.B. Neeves, S.F. Maloney, S.L. Diamond, S.P. Kunapuli, J. Ware, L.F. Brass, T.E. Smithgall, K. Saksela, M.L. Kahn. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.  Proceedings of the National Academy of Sciences of the USA, 106 (2009), 21167-21172. PMID: 19940238
  2. L. Zhu, T.J. Stalker, K.P. Fong, H. Jiang, A. Tran, I. Crichton, E.K. Lee, K.B. Neeves, S.F. Maloney, H. Kikutani, A. Kumanogoh, E. Pure, S.L. Diamond, and L.F. Brass. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis.  Arteriosclerosis, Thrombosis, and Vascular Biology, 29 (2009), 1039-1045. PMID: 19390055
  3. C.P. Foley, N. Nishimura, K.B. Neeves, C.B. Schaffer, and W.L. Olbricht.  Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery.  Biomedical Microdevices, 11 (2009), 915-924. PMID: 19353271 
  4. K.B. Neeves, S.F. Maloney, K.P. Fong, A.A. Schmaier, M.L. Kahn, L.F. Brass, and S. L. Diamond.  Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates.  Journal of Thrombosis and Haemostasis, 6 (2008), 2193-2201. PMID: 18983510
  5. K.B. Neeves and S.L. Diamond.  A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood.  Lab on a Chip, 8 (2008), 701-709. PMID: 18432339
  6. U.M. Okorie, W.S. Denney, M.S. Chatterjee, K.B. Neeves, and S.L. Diamond. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow.  Blood, 111 (2008), 3507-3513. PMID: 18203955

2004-2007

  1. KB. Neeves, A.J. Sawyer, C.P. Foley, W.M. Saltzman, and W.L. Olbricht. Dilation and degrada­tion of the brain extracellular matrix enhances penetration of infused polymer nanoparticles. Brain Research, 1180 (2007), 121-132. PMID: 17920047
  2. A.J.H. Spence, K.B. Neeves, D. Murphy, S. Sponberg, B. Land, R.R. Hoy, and M.S. Isaacson. Flex­ible multielectrodes can resolve multiple muscles in an insect appendage. Journal of Neuroscience Methods 159 (2007), 116-124. PMID: 16899299
  3. K.B. Neeves, C.T. Lo, C.P. Foley, W.M. Saltzman, and W.L. Olbricht. Fabrication and character­ization of microfluidic probes for convection enhanced drug delivery. Journal of Controlled Release, 111 (2006), 252-262. PMID: 16476500
  4. S.T. Retterer, K.L. Smith, C.S. Bjornsson, K.B. Neeves, A.J.H. Spence, J.N. Turner, W. Shain, and M.S. Isaacson. Model neural prostheses with integrated microfluidics: A potential Intervention strategy for controlling reactive cell and tissue responses. IEEE Transactions on Biomedical Engineering, 51 (2004), 2063-2073. PMID: 15536908